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Conventional oral iron salts have poor absorption and gastrointestinal side e?ects. Microencapsulated liposomal iron pyrophosphate is a novel compound with enhanced palatability, higher bioavailability, and consequently increased adherence among people with IDA.
Oral Ferric pyrophosphate is indicated for the treatment of iron loss or iron de?ciency to maintain hemoglobin and to reduce the prescribed dose of erythropoiesis-stimulating agent (ESA) required to desired hemoglobin levels.
Introduction:-
Iron de?ciency anemia (IDA) is the most common type of anemia, which is estimated to be as high as 80–90%. Pathophysiologically, IDA is characterized by depletion of iron stores in the body, which ultimately results in an absolute de?ciency of iron in the body and tissues are deprived of iron. Biochemical parameters suggestive of IDA are derangements in serum levels of ferritin, erythrocyteprotoporphyrin, transfer in saturation, and total iron-binding capacity.
· Stage 1 - reduction of iron stores
· Stage 2 - iron-deficient erythropoiesis
· Stage 3 - absolute depletion of iron stores/overt iron deficiency/IDA.
The most common cause of IDA is nutritional deficiency, i.e., poor intake of iron in diet. Although IDA is slow to develop in non-pregnant population, it develops faster in pregnancy since physiological hemodilution is usually present in pregnancy. It was found in a clinical study that perinatal mortality was increased 3 times when maternal Hbwas <8 g/dl as compared to Hb level of 11 g/dl.
Plethora of oral iron salts is available for this purpose,which includes ferrous sulfate, ferrous fumarate, and ferric citrate. Globally, ferrous sulfate is most commonly, prescribed iron salt for prophylaxis and treatment of IDA. Although efficacy of these conventional iron salts is well established, the gastrointestinal intolerance caused by them is an add on problem. These adverse e?ects are comprised diarrhea, dyspepsia, nausea, vomiting, constipation, abdominal pain, and blackish discoloration of stools. Moreover, absorption of conventional iron salts is hampered by the presence of phytates, calcium and tannins in the food by converting absorbable ferrous form to comparatively less absorb able ferric form through oxidation reaction. In pursuit of overcoming these short comings, newer iron salts such as ferrous as corbate, iron polymaltose complex, and
ferric pyrophosphate were introduced, of which ferric pyrophosphate is the recent one and has shown promising results in clinical studies. The present survey was initiated in pursuit of analyzing the e?ectiveness and safety of oral ferric pyrophosphate (FPP) formulation given once to twice daily in the treatment. To the best of our knowledge, the present survey is the first of its kind to analyze the e?ectiveness and safety of FPP alone in pregnant women with large sample size.
What is Ferric Pyrophosphate used for?
· hemodialysis
· Renal Dysfunction
· Hypotension Secondary to Hemodialysis
· Iron Deficiency
What is the most important information I should know about Ferric Pyrophosphate?
You should not use ferric pyrophosphate if you have ever had a severe allergic reaction to any injected iron product.
Tell your doctor if you have ever had:
· liver disease; or
· high blood pressure.
Ferric pyrophosphate may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine, and for at least 2 weeks after your last dose.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
What are the side effects of Ferric Pyrophosphate?
Get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
· bleeding around your dialysis vein access point;
· blue-colored skin, bulging purple-colored veins that you can see through your skin;
· swelling in your arms, legs, or fingers;
· unusual bleeding or bruising, coughing up blood;
· a light-headed feeling, like you might pass out;
· fever; or
· pain or burning when you urinate.
Common side effects may include:
· headache, dizziness;
· swelling in your hands or feet;
· weakness, tiredness;
· muscle pain;
· feeling short of breath; or
· pain in your back, arms, or legs.
Can I take Ferric Pyrophosphate if I’m pregnant or breastfeeding?
Ferric pyrophosphate may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine, and for at least 2 weeks after your last dose.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
FAQ
What is the most important information I should know about Nephrio?
You should not use this medicine if you have ever had a severe allergic reaction to any iron product.
What is ferric pyrophosphate?
Ferric pyrophosphate is intended to be indicated for the treatment of iron loss or iron deficiency as a formulation with a milder gastrointestinal e?ect.
Can I take Nephrio if I’m pregnant or breastfeeding?
Ferric pyrophosphate may harm an unborn baby. Use e?ective birth control to prevent pregnancy while you are using this medicine, and for at least 2 weeks after your last dose.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
How to take Ferric Pyrophosphate (Nephrio)?
Use Ferric Pyrophosphate (Nephrio) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
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